After revealing initial interest in various fields of studies (youngest awarded baccalauréat in France at the age of 14, and a PhD in Mathematics obtained at the age of 19), Samuel Sené trained at the Music Academies of Orléans and St-Maur before entering the Conservatoire de Paris where he won multiple awards with honours for piano, accompaniment and orchestra conducting, which he studied with Larry Blank.

His professional experience started as a Musical Director Assistant for various opera or operetta productions in France such as "Les contes d'Hoffman" at Paris Bercy, "Olé! Carmen" at France National Stadium or "Le Paris d'Aziz et Mamadou" at Opéra Bastille. He was later engaged to conduct "Carmen", "Orphée aux enfers", "Orphée and Eurydice", "Hamlet", "I pagliacci", "La belle Hélène", "Tosca", "Death in Venice" and "Norma".

Samuel's following career promptly turned to musical theatre. He took the musical direction of the French productions of "Fame", "A Fiddler on the Roof", "She Loves Me", "West Side Story", "Elegies for Punks, Angels and Raging Queens", and is currently working on "First Date" and "The Last Five Years". Among other notable appearances, he was the Musical Director and Vocal Coach for the French originals of "The Marius Awards", "Revolution", "Les Légendes Parisiennes" and "Hashtags". He also briefly appeared as a Choir Master for "Broadway Lights", a show conducted by David Charles Abell at the Théâtre du Châtelet in Paris.

Samuel has conducted a number of notable concerts and events, such as the official Star Wars concert for the release of Episode 3 as well as the final concert for the "Jules Verne Adventures Festival". He is a regular guest to conduct orchestras in São Paulo, Brasil.

He is an accomplished composer to have written several musicals including "Le dernier jour" inspired by a novel by Victor Hugo (National Award of Composers from SACD Paris), "Le Noël Magique" performed at Palais des Congrès of Paris, or "Derviche mon amour", a dance show by Kawtar Kel. He won the European La Scala-Aslico award for writing arrangements for a younger audience version of Wagner's "Die Fliegander Hollander" published by Ricordi-Universal.

He is Musical Director of Musidrama, a professional musical theatre school in Paris, in which he teaches regular courses and masterclasses.

In London, he created the “West End Frenchies”, to unite all French speaking musical theatre writers and performers living in London. He is musical director for the “Voilà” Festival at the Cockpit Theatre, for concerts at the "France Show", for “Pinot! the musical” for schools. He also created the "Voulez-vous sing with me tonight", a monthly event : Cabaret First Set + Open-Mic.